Observations on The Ultrastructural Changes of Carcinogenesis in Golden Hamster Cheek Pouch / 昆明医科大学学报

ABSTRACT

Observations were made on the cheek pounches painted with DMBA of 30 golden hamsters for twelve weeks.Histopathological and ultrastructural results of carcinogenesis were observed.With the occurrences of hyperplasia dysplasia and carcinom, a progressively increased euchromatin,nuclearcytoplasmic ratio and increased number of polyribosomes could be observed. However,the number of tonofibrils,desmosomes,heterochromatins and chondriosomes was decreased.Enlarged and multiple nucleoli and mitosis could be seen. Basement membrane was absent in some areas.In a word,the epithelium underwent a progressively active proliferation and poor differentiation during the carcinogenesis