Effect of agkistrodon antithrombotic enzymes (Svate) on renal microcirculatory perfusion in hemorrhagic shock animals / 中国病理生理杂志

ABSTRACT

The microcirculatory perfusion of liver, spleen, kidney, small intestine andtail were measured by a laser doppler flowmeter after intravenous injection of agkistro-don antithrombotic anzyme (0. 05 U, 0. 025 U/100 g B. W.) in 40 hemorrhagic shockrats and 15 hemorrhagic rabbits. The results showed that 5～20 min after injection therenal perfusion increased significantly, but there was no marked increase of renal arteryblood flow when it was simultanously detected with a electromagnetic flowmeter, thoughthe urine was increased. Authors suggested that Svate may have decreased the resistenceof renal microcirculation and accelerate the veosity of renal microcirculation, thus theyincreased the microcirculatory perfusion in renal cortex.