Effects of captopril on free radical production and it's immune function / 中国病理生理杂志

ABSTRACT

Captopril (CPT, 40, 80mg/kg, ig) enhanced serum superoxide dismutaseactivity, and suppressed luminal-dependent chemiluminescence of peritoneal macrophagesin mice. CPT (160mg/kg, ig) had a suppressive action on lipid peroxidation of mice. Theseresults suggested that CPT had antioxygen free radical effect or anti-lipid peroxidationeffects. CPT at 25 ?g/ml concentration suppressed ConA-induced prolifeation of mousesplenic T lymphocytes in vitro, which suggested that CPT had a suppressive effct on Tlymphocyte function.