The calcium antagonism of radix salviae miltirrhiziae (RSM) in antihepatocellular necrosis / 中国病理生理杂志

ABSTRACT

In this study, carbontetrachloride was administered orally to male Wistarrats at a dose of 2.5ml/kg body weight. The protective effects of RSM were comparedwith that of verapamil (a well-known calcium antagonist), and regitine (a vasodilator),to study the mechanisms of RSM action. The results showed that a significant correlation between CCl_4-induced liver tissuenecrosis and liver tissue calcium content(r=0.887, P