Detection of Serum Beta endorphin and its Clinical Significance in Patients with Psoriasis / 中华皮肤科杂志
Chinese Journal of Dermatology
;
(12)1994.
Article
in Chinese
| WPRIM
| ID: wpr-516471
ABSTRACT
In order to study the possible role of beta endorphin (? EP) in the pathogenesis of psoriasis, serum ? EP was detected by radioimmunoassay in 51 patients with psoriasis and 32 healthy controls. The results showed that serum ? EP level was markedly increased in patients with psoriasis in comparison with healthy controls. The serum ? EP level was reduced when the skin lesions of the patients were cleared after treatment, however, it was still higher than in healthy controls. Although there was a tendency towards an increase of ? EP in patients with precipitating factors in comparison with those without precipitating factors, their levels were not significantly different. There was a negative correlation between the intensity of pruritus and ? EP levels. It is suggested that ? EP involves in the pathogenisis of psoriasis. Its production and release were controlled by the central nervous system and also affected by the inflammation of skin lesions. There might be a causality between ? EP levels and inflammatory reaction of skin lesions.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
Language:
Chinese
Journal:
Chinese Journal of Dermatology
Year:
1994
Type:
Article
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