Increased lymphocyte interleukin (IL -2) activity in guinea pigs with ovalbumin (OVA) - induced bronchial asthma / 中国病理生理杂志

ABSTRACT

Airway inflammation in atopic asthma is characterized by T -cell activation, leading to the release of certain cytokines. In this study the IL-2 activity and IL-2 mRNA express in the lymphocytes in guinea pigs with OVA -induced bronchial asthma was measured. It was found that eosinophils and lymphocytes were predominant cells in the peritoneal lavage fluid and bronchoalveolar lavage fluid (BALF) in asthmatic guinea pigs. Compared with contol group, the IL-2 activities in lymphocytes from the BALF (22.56? 2.44 ng/ml vs 14.23 ?4.71ng/ml, P