Effects of isoflurane,propofol and mild hypothermia on glutamate releases evoked by chemical anoxia in hippocampus brain slices of rats / 中华麻醉学杂志
Chinese Journal of Anesthesiology
;
(12)1996.
Article
in Chinese
| WPRIM
| ID: wpr-516703
ABSTRACT
Objective:
To determine whether mild hypothermia,isoflurane and propofol reduce gultamate release in rat hippocampus brain slices after hypoxia.Method:
Brain slices preparations were separated and incubated from rat hippocampus. Glutamate released from rat brain slices during chemical anoxia(100?M KCN)were measured with a fluorescence assay,at 28℃,31℃ and 37℃ after anoxia and after administration of 1 MAC of isoflurane and 200 ?m propofol respectively.Result:
Glutamate release was significantly reduced at 28℃ or 31℃ compare with that at 37℃ (P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Anesthesiology
Year:
1996
Type:
Article
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