Effects of midazolam-induced sedation on heart rate variability / 中华麻醉学杂志
Chinese Journal of Anesthesiology
;
(12)1996.
Article
in Chinese
| WPRIM
| ID: wpr-516712
ABSTRACT
Objective:
To examine the effects of midazolam-induced sedation on heart rate variability (HRV).Method:
Fifteen ASA Ⅰ- Ⅱ adult patients,undergoing elective surgery under lumbar epidural anesthesia were randomly selected. An intravenous bolus dose of midazolam(1.5mg) was administered every 3-5 minutes until patients' sedation levels assessed by observers assessment of alertness sedation(OAA/S) scale had scores of 1. Spectral analysis of HRV was performed at different OAA/S scores and at 3min,5min and 10min following OAA/S score of 1.Result:
All frequency components of HRV were significantly reduced as patients' OAA/S scores decreased,especially low frequency (LF) and total power. Midazolam decreased normalized unit power of LF from 33.5%?8.9% to 16.65?9.6% and increased normalized unit power of high frequency(HF) from 11.7%?4.2% to 20.5%?26.5%. LF/HF ratio also reduced.Conclusion:
Midazolam shiftes the balance of autonomic nervous activity toward the parasympathotonic.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Anesthesiology
Year:
1996
Type:
Article
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