Epidural triamcinolone in relieving long-term advanced cancer pain combined with morphine and it's pharmacokinetic study / 中华麻醉学杂志

ABSTRACT

To investigate epidural morphine(M) combined with triamcinolone A(TA) for advanced cancer pain and to study pharmacokineties of TA. Method.. TA 40mg/w was epidually combined with M3.84?3.94mg/d in 104 advanced cancer patients and TA blood concentration was measured with high performance liquid chromatography. Result: The rate of adverse reaction was 7.69% and visual analog scale was 3.16?2.83. The plasma elimination half life (t_(1/2)) was 1.63?0.36d; plasma accumulation coefficient (R) was 1.06-1-0.04?g/ml. Conclusion: The analgesic effect of M is potentiated by TA and there is no TA accumulation in plasma following long-term epidural administration.