Effects of propofol on coronary circulation of acute myocardial ischemia-reperfusion injury in canines / 中华麻醉学杂志

ABSTRACT

Objective: To evaluate the effect of propofol on coronary circulation of acute myocardial ischemia-reperfusion inury. Metbod 18 hybrid dogs (11-14kg) were divided randomly into three groupsNS group (normal saline, 2ml?kg~(-1)?h~(-1)), HP group (high-dose propofol, 11.2mg?kg~(-1)?h~(-1)), LP group (low-dose propofol, 5.6mg?kg~(-1) ?b~(-1)). These dogs were subjected to 90 min left anterior descending coronary artery (LAD) occlusions followed by 200 min of reperfusions. Before administration, 60 min after administration, 60min, 120min, 180min following reperfusion,coronary circulation was assessed by measurement of coronary perfusion pressure (CPP) and blood flow of LAD. Result: The values of CPP in HP and LP groups 60 minafter administration were significantly lower than those in NS group before LAD occlusion (P