Effeets of ProPofol on left ventrieular funetion of aeute myoeardial isehemia-reperfusion injury in canines / 中华麻醉学杂志

ABSTRACT

objective:To evaluate the effeets of Propofol on left ventrieular funetion of aeute myoeardial isehemia-reperfusion injury in eane.Method:Eighteen hybrid dogs(11一14kg)were divided randomly inro three groupsNSgroup(norrnal saline,Zml?kg一l?h一1),HP group(high一dose propofol,11.Zmg?kg一1?h一1),LP group(low一dosepropofol,5.6mg?kg一'?h一').These dogs were subjeeted to a 90一min left anterior deseending eoronary artery oeelu-5 ion followed by 200min of rePerfusion.Before ad而nistrat一on,60min after administration,at oeelusion一90min and60min.12Ornin and180min壬ollowing reperfusion left ventrieular funetion was assessed by measurement of LVSP,LVEDP,dp/dtmax and dP/dtmin.Result:Compared with the baselines,LVSP,dp/dtmax and dP/dtmin 60 min afteradrninistration deereased byg%,17%and 17%respeetively,LVEDP inereased by 80%in HP grouP.120min and180min during reperfusion LVSP.dp/dtmaxanddp/dtmininHPandLPgroupweresignifiea八tlyhigherthanthoseinNs group。.05),LvEDP signifieantly lower than that in NS group(p