Protective effect of taurine on gut barrier: an experimental study / 中华麻醉学杂志

ABSTRACT

Objective: To study protective effect of taurine on gut barrier after hemorrhagic shock-reperfusion. Method: Twenty-four white rabbits were divided randomly into 3 groups taurine group (A),shock group (B), control group (C). Result: Malondialdehyde and Ca~(2+) contents of intestinal mucosa remained unchanged in group A, but increased significantly in group B, Incidence of bacterial translocation in B group was markedly higher than that in C group at 30 min following reperfusion. Under light and electronic microscope,in comparsion with A and C groups,intestinl mucosa damage in B group became more severe. Conclusion: Taurine can protect gut barrier from intestinal ischemia reperfusion injury induced by hemorrhagic shock through reducing oxide free radical and preventing calcium overload.