Effects of propofol on macrescopic sodium currents in rat sympathetic neurons / 中华麻醉学杂志
Chinese Journal of Anesthesiology
;
(12)1996.
Article
in Chinese
| WPRIM
| ID: wpr-517087
ABSTRACT
Objective To study the effects of propofol on the whole-cell sodium currents in rat sympathetic neurons in order to investigate the mechanisms of propofol-mediated peripheral vasodilation.Methods Whole-cell patch-clamp recordings were made from enzymatically isolated rat superior cervical sympathetic neurons.Results Propofol dose-dependently blocked the whole-cell sodium currents evoked by a voltage step from a holding potential of -- 80mV to 0mV with a mean IC50 value of 32. 19?mol/L (r = 0. 982, P
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Anesthesiology
Year:
1996
Type:
Article
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