Effect of captopril and betaloc on the changes in expression of MHC of left ventricle in hypertensive rats / 中国病理生理杂志

ABSTRACT

AIM:To investigate myosin heavy chain(MHC)gene expression and the effects of captopril and betaloc at an early stage of hypertension. METHODS:Model of hypertension was made by partly narrowing two bilateral renal arteries(2K2C). The rats were divided into four groups at random. (1) control group; (2)2K2C group;(3)captopril group;(4)betaloc group.Levels of ?-MHC and ?-MHC mRNA were determined by dot-blot. RESULTS:?-MHC mRNA expression were gradual1y reduced in 2K2C group,while ?-MHC mRNA expression were increased,and the marked changes were observed at 72h postoperation. Captopril could inhibit the changes in MHC gene expression; but betaloc could not. CONCLUSION: The expression of MHC gene has changed at an early stage of renal hypertensive rat,and renin-angiotensin system may play an important role in this change.