Effects of anesthesia and operation on renal glomerular and tubular function / 中华麻醉学杂志

ABSTRACT

Objective To investigate the effects of anesthesia and operation on glomerular and renal tubular function Methods Forty patients without renal disease were assigned to 4 groups: general anesthesia + minor operation; general anesthesia +major operation; epidural block + minor operation and epidural block + major operation The concentration of ?_2-microglobulin(?_2-MG)、albumin(Alb)and immunoglobulin G(IgG)in urine were measured before operation ,1h following operation and 24h after operationResults In the groups of major operation, the concentrations of ?_2-MG, Alb and IgG in urine increased significantly during and after operation(P005)Conclusions The influences on renal glomerular and tubular function during perioperation are related to the degree of operative stimulation, but do not to the anesthesia