Lipopolysaccharide stimulates TNF? and endothelin-1 secretion from cultured rat kupffer cells / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)2000.
Article
in Chinese
| WPRIM
| ID: wpr-517284
ABSTRACT
AIM:
To investigate LPS(lipopolysaccharide)stimulated cytokine secretion from normal rat kupffer cells in vitro.METHODS:
Kupffer cells were isolated from wistar rats liver and cultured.Tumor necrosis factor -? (TNF-?) and endothelin-1(ET-1) secreted by LPS stimulated kupffer cells were detected.RESULTS:
LPS had an stimulative effect on kupffer cell activity. LPS in definite concentrations promoted kupffer cell secretion.CONCLUSION:
LPS promotes kupffer cell secretion, which may be associated with liver injury induced by LPS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
2000
Type:
Article
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