Effects of Tripterygium wilfordii on the Production and Activities of IL- 1 and IL- 2 in vitro / 中华皮肤科杂志
Chinese Journal of Dermatology
;
(12)1994.
Article
in Chinese
| WPRIM
| ID: wpr-517395
ABSTRACT
Objective To investigate the effects of the compound T0 extracted from Tripterygium wilfordii, a traditional Chinese herb, in comparison with those of cyclosporin A(CyA), on down- regulating the expression and activities of IL- 1 and IL- 2. Methods The cellular reactive systems of peritoneal macrophage (rat)- thymocytes (rat), and spleen cells (rat)- CTLL- 2 (mouse) were set up. The technique of 3H- TdR incorporation was applied. Results The production of IL- 1 and IL- 2 were significantly inhibited by T0 and CyA. The activities of IL- 1 and IL- 2 were down- regulated by T0,rather than by CyA. Conclusion T0 and CyA are potent inhibitors of the production of IL- 1 and IL- 2. Effects of T0 on the activities of IL- 1 and IL- 2 are different from those of CyA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Dermatology
Year:
1994
Type:
Article
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