The Inhibitory Effect of Dihydro-?-erythroidine on Nicotine Induced-current in Cultured Sympathetic Neurons

The Inhibitory Effect of Dihydro-?-erythroidine on Nicotine Induced-current in Cultured Sympathetic Neurons / 中国药房

Wei LIU; Jianquan ZHENG; Zhenwei LIU; Lijun LI; Chuanhui LIU.

China Pharmacy ; (12)1991.

Article in Chinese | WPRIM | ID: wpr-517420

ABSTRACT

AIM:

To investigate the inhibitory effect of dihydro-?-erythroidine on nicotine induced-current in cultured superior cervical ganglion of neonatal rats.

Pneumatic pressure administration of drug and whole-cell recording techniques were performed to compare induced-current amplitude.

Dihydro-?-erythroidine competitively antagonized nicotinic effect,and EC50 was about 0.015mmol/L.

Dihydro-?-erythroidine is a competitive antagonist of nicotinic receptors in sympathetic neurons.

whole-cell recording; induced-current; dihydro-?-erythroidine; superior cervical ganglion cell; nicotinic receptor; competitive antagoni

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 1991 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 1991 Type: Article