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Activation of NF-? B Signaling Pathway in Peripheral Blood Mononuclear Cells of Patients With Systemic Lupus Erythematosus / 中华皮肤科杂志
Chinese Journal of Dermatology ; (12)1995.
Article in Chinese | WPRIM | ID: wpr-517486
ABSTRACT
Objective To detect the activation of NF-? B signaling pathway in peripheral blood mononuclear cells(PBMCs) of patients with systemic lupus erythematosus(SLE) and investigate its clinical significance. Methods Activation of NF-? B was detected by electrophoretic mobility shift assay( EMSA), the expression of I? B? protein and its phosphorylated products were detected by Western blot. Anti-dsDNA antibody, IgG and IgM in supernatant of PBMC culture were tested by ELISA. Results (1)Elevated activation of NF-? B in PBMC of SLE patients was found when compared with the controls(P

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Dermatology Year: 1995 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Dermatology Year: 1995 Type: Article