Experimental study on effects of ATP and its derivatives on the proliferation of the immortalized human fibroblasts / 中国病理生理杂志

ABSTRACT

MeATP=BzATP, neither 2-MeSATP nor UTP showed any cytotoxicity. No enhanced expression of P 21 was observed and the cell cycle was held in G 1/S in the cells treated with 0.4mmol/L;no cell apoptosis was detected in the cells treated with 1mmol/L ATP. CONCLUSION: Connecting with P 2X or P 2Y purinergic receptors,ATP activated some intracellular signals to inhibit cell growth, the growth inhibition caused by ATP was not due to apoptosis or induction of cyclin/CDK kinase inhibitor,P 21 .