Effect of Sodium Magnesium Fructose Diphosphate on ATP, ADP and AMP in Tissue of Myocardial In-farction / 中国药房

ABSTRACT

OBJECTIVE: To investigate whether sodium magnesium fructose diphosphate(SM) could raise the contents of energy sustrates-ATP, ADP and AMP in the tissues of acute myocardial infarction.METHODS: 60 rat models of acute my-ocardial infarction were randomly divided into 6 groups(n = 10) Treatment groups( A, B, C) received SM(75mg/kg, 38mg/kg and 19mg/kg) in saline sulution respectively,and control groups(D.E) received 1,6-fructose diphosphate(200mg/kg) or mag-nesium sulfate( l0mg/kg) ,another control(F) received same volume of saline.Four hours after administration, the levels of AT-P.ADP and AMP in the myocardial homogenate were determined by HPLC.RESULTS:The levels of ATP, ADP and AMP of treatment groups(A, B, C) were (612.8? 103.2), (538.0??141.2) and (325.2 ? 113.2) nmol/g; (407.6?113.4), (389.4 ? 91.5), (306.1??34.6) nmol/g and (1 637.6? 236.8), (1 366.8??279.3), (1 186.1 ??341.1) nmol/g; while those of control groups(F) were (119.0 ? 22.8), (146.5??36.8) , (436.7 ? 214.9) nmol/g, respectively(P