Analysis of 967 Cases of Drug-induced Ophthalmic Injuries / 中国药房

ABSTRACT

OBJECTIVE:To review the occurrence of ophthalmic injuries and analyse the relationship between the injuries and the kinds of drugs used and the route of administration METHODS:The cases of drug-induced ophthalmic injuries which were reported in medical journals published from 1960 to 2000 year were collected and analysed RESULTS:There were 967 cases of drug-induced ophthalmic injuries caused by 154 kinds of drug The clinical manifestations of ophthalmic injuries included ocular pigmentation,visual disturbance,loss of sight and injuries to cornea,conjunctiva,optic nerve,retina or optic papilla,and the inducing drugs were mostly antimicrobials,central nervous system and circulatory system drugs,such as chlorpromazine,perphenazine,amiodaron,ethambutol etc CONCLUSION:Drug-induced ophthalmic injuries caused by systemic administering drugs in commonly-used dosage and route pertain to ADRs The ophthalmic injuries caused by local application of drugs to the eyes result from improper drugs used,faulty manipulation and unsuitable applications of drugs during or after operations