Inhibitory Effect of Tumor Necrosis Factor and Interferon with Chemotherapeutic & Radiotherapy on the Growth of Tongue Cancer Cell in Vitro / 中国医师杂志

ABSTRACT

Objective To investigate the role and feasibility of tumor necrosis factor(TNF) and/or interferon(IFN) in comprehensive treatment of tongue cancer in vitro and explore a new pathway about clinical treatment of tongue cancer . Methods The role of TNF and/or IFN in tongue cancer cell line (Tca 8113) growth and their effect on chemotherapy & radiotherapy of Tca8113 were detected by MTT-assay in vitro.Results ⑴There was a obvious volume-effect relationship in inhibitory effect of TNF or IFN on tongue cancer cell line; when TNF combind with IFN,their cytotoxity enhanced significantly than only TNF or IFN. ⑵TNF & IFN have enhanced the cytotoxities of low dose DDP,PLM and Taxol on Tca 8113 cell line.⑶TNF obviously enhanced the inhibition rate of radiotherapy(dosage2～8Gy)on Tac 8113 cell line(P