The Clinical Significance of Cyclooxygenase 2 Expression in Colorectal Cancer
Journal of the Korean Surgical Society
;
: 39-43, 2003.
Article
in Korean
| WPRIM
| ID: wpr-51804
ABSTRACT
PURPOSE:
Epidemiologic studies have indicated that the use of nonsteroidal anti-inflammatory drugs, which inhibit cyclooxygenase activity, reduce the risk of colorectal cancer. In addition, several studies have demonstrated the increased expression of cyclooxygenase-2 (COX-2) in human colorectal cancer tissues. However, the role of COX-2 in colorectal cancer has not been fully established. The aim of this study was to clarify the clinicopathologic significance of COX-2 expression in human colorectal cancer.METHODS:
We performed immunohistochemical straining for COX-2 expression in 124 human colorectal cancer specimens. COX-2 expression was then compared with clinicopathologic factors and survival outcomes.RESULTS:
COX-2 was expressed in the cytoplasm of the cancer cells. COX-2 expression was noted in 86.3% of the cancer patients and significantly correlated with the histologic type. The depth of invasion, tumor size, lymph node metastasis and stage were not correlated with COX-2 expression. Multivariate analysis for the factors associated with survival showed that serum CEA, size, depth and lymph node involvement correlated with survival, but COX-2 expression had no correlation.CONCLUSION:
These data suggest that COX-2 expression in primary lesion of colorectal cancer may not be a useful marker for evaluating prognosis. However, further studies are necessary for identification of the roles in colorectal carcinogenesis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Immunohistochemistry
/
Colorectal Neoplasms
/
Epidemiologic Studies
/
Multivariate Analysis
/
Prostaglandin-Endoperoxide Synthases
/
Cytoplasm
/
Cyclooxygenase 2
/
Carcinogenesis
/
Lymph Nodes
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Surgical Society
Year:
2003
Type:
Article
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