Your browser doesn't support javascript.
loading
Role of macrophage and intercellular adhesion molecule-1 in the pathogenesis of oleic-acid-induced rat acute lung injury / 中国病理生理杂志
Chinese Journal of Pathophysiology ; (12)1999.
Article in Chinese | WPRIM | ID: wpr-518118
ABSTRACT

AIM:

To investigate the role of infiltration of macrophages and expression of intracellular adhesion molecule-1 in the pathogenesis of oleic-acid-induced acute lung injury rats.

METHODS:

The rats were subjected to injection of oleic acid (oleic acid group) or saline solution (control). After injecting oleic acid or saline for 4 hours, the PaO 2 of the left heart, lung permeability index(LPI), the number of macrophage and the levels of soluble intercellular molecule-1 (sICAM-1) in the bronchial alveolar lavage fluid (BALF) were measured. The levels of expression of ICAM-1 mRNA were evaluated by in situ hybridization and the degree of macrophage infiltration and the expression of ICAM-1 were evaluated by double staining immunocytochemistry.

RESULTS:

The PaO 2 of the oleic acid group was significantly lower than that of the control group (P

Full text: Available Index: WPRIM (Western Pacific) Type of study: Etiology study Language: Chinese Journal: Chinese Journal of Pathophysiology Year: 1999 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Type of study: Etiology study Language: Chinese Journal: Chinese Journal of Pathophysiology Year: 1999 Type: Article