Three kinds of antisense oligodeoxynucleotide enhance the sensitivity of leukemia cell K562 to cisplatin / 中国病理生理杂志
Chinese Journal of Pathophysiology
; (12)1999.
Article
in Zh
| WPRIM
| ID: wpr-518129
Responsible library:
WPRO
ABSTRACT
AIM: To investigate whether antisense oligodeoxynucleotides of hTERT?bcl-2 and c-myc could enhance the sensitivity of leukemia cell K562 to cisplatin. METHODS: The inhibiting effects of cisplatin and cisplatin plus antisense oligodeoxynucleotide on K562 cells were determined by MTT. RESULTS: The inhibiting rate of 20 ?mol/L cisplatin to K562 cell is 17.17%?1.36% and it becomes 25.41%?1.77% ,26.18%?1.43% and 28.29%?1、05%, respectively, as combinated with antisense oligodeoxynucleotide of hTERT?bcl-2 or c-myc. CONCLUSION: These results indicated that antisense oligodeoxynucleotides of hTERT?bcl-2 and c-myc enhanced efficacy of cisplatin in K562 leukemic cells.
Full text:
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Index:
WPRIM
Type of study:
Diagnostic_studies
Language:
Zh
Journal:
Chinese Journal of Pathophysiology
Year:
1999
Type:
Article