The Effects of N-acetylcysteine on Plasma Amino-acids in Animals With Fulminant Hepatic Failure / 中国药房

ABSTRACT

OBJECTIVE:To investigate the relationship between therapeutic effects of N-acetylcysteine(NAC) on animals with fulminant hepatic failure and contents of plasma amino-acids METHODS:Plasma amino-acids were analysed as their precolumn derivatives with O-phthol-dialdehyde by reversed-phase high-performance liquid chromatographic separation and fluorescence detection RESULTS:NAC could decrease the contents of plasma amino-acids,increase the ratio of BCAA/AAA and decrease the mortality of fulminant hepatic failure animals CONCLUSION:Therapeutic effects of NAC on animals with fulminant hepatic failure were related to its effect on the contents of plasma amino-acids