Preparation of Rapid-release and Sustained-release Bilayer Tablet of Alfuzosin Hydrochloride / 中国药房

ABSTRACT

OBJECTIVE:To determine the formula of alfuzosin rapid-release and sustained-release bilayer tablet and its preparation METHODS:The compositions of rapid-release layer were selected by orthogonal design and the compositions of sustained-release layer were determined according to its percentage of dissolution RESULTS:The rapid-release layer contained alfuzosin 1mg,lactose 35mg,sodium carboxylmethyl starch 1mg and starch 8mg The sustained-release layer contained alfuzosin 4mg,HPMC 50mg and MC 70mg CONCLUSION:The formula of the tablet is reasonable and the preparation simple