Vascular endothelial growth factor in ocular fluid of patients with neovascular glaucome / 中华眼底病杂志

ABSTRACT

Objective To detect the levels of vascular endothelial growth factor (VEGF) in aqueous humor and vitreous of patients with neovascular glaucoma (NVG) and infer their possible effect on the development of neovascularization of iris. Methods The concentration of VEGF in 22 samples of ocular fluid of aqueous humor and vitreous respectively obtained from 11 patients with NVG undergone intraocular surgery were measured by using enzyme linked immunosobent assay (ELISA) for quantitative analysis. As control, 12 samples of ocular fluid of 6 patients with macular hole were detected by the same methods. Results The mean ?s VEGF concentrations in aqueous humor and vitreous from patients with NVG were [(1.451?0.247)?(1.610?0.125) ng/ml] higher than those in the cotrol group [(0.189?0.038)?(0.201?0.055) ng/ml], there was a significant difference between the two groups statistically ( t=12 007, P