A Clinicopathologic Study of Ovarian Malignant Germ Cell Tumor / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 3023-3028, 1998.
Article
in Korean
| WPRIM
| ID: wpr-51838
ABSTRACT
From Jan. 1984 to Dec. 1993, 46 patients with malignant germ cell tumor of ovary were identified in tumor registry of Seoul National University Hospital. The clinicopathologic features of these patients were reviewed. The mean age of patient was 21.6 years (range 1-54), and common presenting symptoms were abdominal mass (19/46), abdominal pain (9/46), abdominal distension (7/46), and epigastric discomfort (2/46) in order. Dysgerminoma was the most common histologic type (19/46, 41.3%), followed by endodermal sinus tumor (13/46, 28.2%), mixed germ cell tumor (6/46, 13/0%), embryonal carcinoma(5/46, 10.8%), immature teratoma(2/46, 4.3%), and chorio- carcinoma (1/46, 2.1%). Among 6 mixed germ cell tumors, dysgerminoma mixed with endodermal sinus tumor component was the most frequent combination. Fifty percent of patients were with FIGO stage I, and 26% with stage III. Overall two year disease free survival was 89.1%. Patients with dysgerminoma showed more favorable 2 year disease free survival (100%) than endodermal sinus tumor or mixed germ cell tumor (84.6%, 66.6% respectively). Patients age, disease stage, histologic type and future child-bearings should be considered in the management of malignant ovarian germ cell tumor. Multicenter prospective randomized studies are needed to identify the more rational treatment strateges of these rare malignant tumors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ovary
/
Abdominal Pain
/
Endodermal Sinus Tumor
/
Neoplasms, Germ Cell and Embryonal
/
Disease-Free Survival
/
Dysgerminoma
/
Seoul
/
Germ Cells
Type of study:
Controlled clinical trial
Limits:
Female
/
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
1998
Type:
Article
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