The potential role of neurotrophic factor in the pathogenesis and therapy of Parkinson's disease / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)1986.
Article
in Chinese
| WPRIM
| ID: wpr-518557
ABSTRACT
Parkinson's disease is characterized by degeneration and dysfunction of dopaminergic neurons in the mid-brain substantia nigra, neurons that project to the caudate putamen. The clinical symptoms are caused by the loss of dopamine and the consequent dysfunction of the nigrostriatal pathway. Neurotrophic factors that may prevent nigrostriatal degeneration by improving the function of remaining dopaminergic neurons has the potential to be a useful therapy for Parkinson's disease. Neurotrophic factors and their specific receptors could play an important role in the progress of Parkinson's disease. The neuroprotective effects of neurotrophic factors GDNF, BDNF, IL-6 on dopaminergic neurons in vivo and in vitro , and the potential therapeutic use in treating Parkinson's disease were discussed in this paper.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
1986
Type:
Article
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