Down-regulation of ?-defensin-2 gene expression in E.coli-infected rat lung tissue / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)1986.
Article
in Chinese
| WPRIM
| ID: wpr-518559
ABSTRACT
AIM:
To study the regulation of rat ?-defensin-2 gene expression by bacteria.METHODS:
E.coli ML-35 p and pseudomonas aeruginosa were injected into rat trachea. Total RNA was isolated from lung tissue after 24 h inoculation. RT-PCR and Northern blot were performed to detect ?-defensin-2 ( rBD-2 ) mRNA expression.RESULTS:
The expression of rBD-2 gene was inhibited in the lung tissue by E.coli infection, but not by pseudomonas aeruginosa.CONCLUSION:
These results indicated that E.coli infection could down-regulate rBD-2 gene expression in the rat lung tissues.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
1986
Type:
Article
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