Effect of ?-amyloid protein on the fluidity of mitochondrial membrane in hippocampus of aging rats induced by D-galactose / 中国病理生理杂志

ABSTRACT

AIM: To study the effect of ?-amyloid protein (?-AP) on the fluidity of mitochondrial membrance in hippocampus of the aging model of rats.METHODS: Based upon the model of aging rats induced by D-galactose (D-gal) and hippocampal microinfusion of ?-AP, the behaviors of rats were observed. Using DPH as fluorescent probe, the viscous cofficient (?) of mitochondrial membrane was determined, and Na +-K +ATPase activity was measured.RESULTS: In the D-gal+?-AP group rats, Na +-K +ATPase activity was lower than D-gal and ?-AP groups ( P