Oxidative modification of low density lipoprotein induced by hyperhomocysteinaemia following application of methionine / 中国病理生理杂志

ABSTRACT

AIM: To observe the oxidative modification of low density lipoprotein iinduced by hyper homocysteinaemia following application of methionine. METHODS: Thirty two rabbits were randomized as group methionine(group M, n =9), group cholesterol (group Ch, n= 9), group methionin+cholesterol (group M+Ch, n= 9) and control group (group C, n= 5).In group M, Ch and M+Ch, the animals were fed with the food containing 3% methionine, 3.75% cholesterol and 3% methionine+3.75% cholesterol, respectively. By the end of sixteen weeks, the blood were taken and the measurements were carried out. RESULTS: Following application of methionine, the levels of hyperhomocysteine, ox-LDL and TBARS in group M and group M+Ch were significntly higher than those of group C and group Ch ( P