Apoptosis in the acute rejection of Hamster-to-Rat liver transplantation / 中国普通外科杂志
Chinese Journal of General Surgery
;
(12)1993.
Article
in Chinese
| WPRIM
| ID: wpr-518586
ABSTRACT
Objective To study the occurrence of apoptosis in acute rejection of hamster-to-rat liver transplantation and the molecular mechanism. Methods On the basis of establishment of hamster-to-rat orthotopic liver transplantation, the apoptosis in xenograft were observed by histology and in situ end-lebelling of fragmented DNA;the expression of Fas-L and TGF-?1 were observed by Immunohistochemistry. Rseults In acute rejection of liver xenograft, the apoptosis of hepatocyte was detectable, meanwhile, the expression of Fas-L and TGF-?1 were found. The more severe apoptosis, the more severe acute rejection , and the more expression of Fas-L and TGF-?1 . Conclusions Apoptosis as a mechanism of cell death exists in the acute rejection of liver xenograft, and it is closely related to the expression of TGF-?1 and Fas-L.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of General Surgery
Year:
1993
Type:
Article
Similar
MEDLINE
...
LILACS
LIS