Simultaneous Determination of Estazolam and Diazepam in Serum With HPLC / 中国药房
China Pharmacy
;
(12)1991.
Article
in Chinese
| WPRIM
| ID: wpr-518634
ABSTRACT
OBJECTIVE:
To establish HPLC method for simultaneous determination of estazolam and diazepam in serumMETHODS:
The mobile phase consisted of methanol-water-triethylamine-acetic acid(55∶45∶0 5∶0 35)and the ?max was 254nm Phenytoin was adopted as the internal standard The drugs were extracted by diethyl ether under the alkaline conditionRESULTS:
The calibrating curves of estazolam and diazepam were linear in the ranges of 0 52~38 62?g/ml and 0 50~40 16?g/ml respectivelyCONCLUSION:
The method was appropriate for determination of estazolam and diazepam qualitatively and quantitatively in intoxication accident
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
1991
Type:
Article
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