The Effects of Mutant p53 Protein Expression on the Pre-operationPatients with Breast Carcinoma Treated with Adriamycin Chemotherapy / 中国医师杂志
Journal of Chinese Physician
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-518737
ABSTRACT
Objective To investigate the influences of mutant p53 protein expression on the resistance of breast cancer cells to adriamycin and efficiency of adriamycin chemotherapy of the pre-operative patients with breast carcinoma.Methods Mutant p53 protein expression in 9 cases of breast cancer was examined by using inmunohistochemical method and image semiquantified analysis.The response of human breast cancer cells to adriamycin was tested with MTT assay in order to judge the effects of mutant p53 protein expression on the pre-operative pateints with breast carcinoma treated with adriamycin chemotherapy.Results ⑴Mutant p53 protein expression in 7 cases of the human breast cancer samples were positive,the positive rate was 77%(7/9).⑵There was positive relationship between expression degree of mutant p53 protein(positive relative area) and resistance index(IC501/10 peak concentration) of human breast cancer cells to adriamycin(r=0 7956,P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Chinese Physician
Year:
2001
Type:
Article
Similar
MEDLINE
...
LILACS
LIS