Assay of Concentration of Isoniazid in Plasma With HPLC / 中国药房
China Pharmacy
;
(12)1991.
Article
in Chinese
| WPRIM
| ID: wpr-518791
ABSTRACT
OBJECTIVE:
A HPLC method has been developed to determine the concentration of isoniazid in plasma.METH_ODSThe Eclipse XDB-C18 column was used as fix phase and acetonitrile-0.05mol/L ammonium dihydrogen phosphate as mo_bile phase,detection wavelength was 280nm.The plasma sample was injected directly for determination after being deproteinized with 10% trichloroacetic acid and reacted with cinnamaldehyde and abstracted with ether.RESULTS:
Good linear relationship was shown from 0.10 to 12.0?g/ml and the averge recovery of isoniazid was 95%~105%.CONCLUSION:
The method is rapid,sensitive and is rarely interfered so it can be used in study of pharmacokinetics of isoniazid.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
1991
Type:
Article
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