The change of serum inflammatory mediators in patients undergoing tension-free inguinal hernia repair / 中国普通外科杂志

ABSTRACT

ObjectiveThis study was to evaluate the changes of inflamatory mediators in patients undergoing tension free hernioplasty(LH) using expanded polytetrafluoroethylene (e PTFE) mycromesh biomaterial or conventional Bassini hernia repair(BH). MethodTwenty one patients randomized into two groups receiving LH or BH. Peripheral venous blood samples were collected 24 hours prior to surgery and then 6,24,48 and 168 hours postoperatively.ResultLH patients showed a higher increased serum level of fibringen,C reactive protein,alpha 1 antitrypsin, and interleukin 6 than BH patients. Postoperative visual analogue scales for pain reduced on mobilization for patients undergoing LH compared with BH. Neutrophils significantly increased only in LH compared with baseline. ConclusionOur data show that although LH induces less pain and rapid postoperative recovery,it is associated with an higher inflammatory response compared with BH, likely due to mycromesh biomaterial.