Inhibitory effects of dexamethasone on the expression of integrin CD18 induced by PMA / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)1989.
Article
in Chinese
| WPRIM
| ID: wpr-519265
ABSTRACT
AIM:
To study the effect of dexamethasone(Dex) on the expression of CD18.METHODS:
Quantitative RT-PCR analysis, Northern blotting technique were used to measure the expression of CD18 in U937 cells treated by PMA.RESULTS:
Dex could significantly attenuated the effects of PMA in a dose-dependent manner (10 -6 mol/L-10 -10 mol/L). These effects of Dex (10 -7 mol/L) were completely aborted by RU-486 (10 -6 mol/L).CONCLUSION:
Dex, via GR, could inhibit CD18 mRNA expression in U937 cells treated by PMA. The effects of Dex might be possibly depended on the counteracting action on the NF-?B.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
1989
Type:
Article
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