Pharmacokinetics of Domestic Cetirizine Hydrocloride Tablet in 11 Healthy Volunteers / 中国药房
China Pharmacy
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-519317
ABSTRACT
OBJECTIVE:
A reversed-phase high performance liquid chromatography(RP-HPLC)method was established to study the pharmacokinetics of cetirizine hydrocloride tablet in 11 healthy male volunteersMETHODS:
Waters HPLC instrument was used with the Waters symmetry C18 steeless column(3 9mm?150mm,5?m) The mobile phase was composed of acetonitrile-0 02mol/L sodium hydrogen diphosphate-triethylamine(50∶50∶0 16,V/V),which contained 4 0mmol/L sodium dodecyl sulphate Flow rate was 1 0ml/min Detection wavelength was 229nm Propafenone was taken as internal standard A single 10mg oral dose of cetirizine hydrocloride tablet was given to 11 healthy male volunteers Cetirizine concentration was assayed in plasmaRESULTS:
The standard curve of cetirizine hydrocloride was linear in the range of 12 5~800ng/ml The minimum detection limitation was 5ng/ml The extraction recovery was more than 75% A two-compartment open pharmacokinetic model was adapted in cetirizine plasma concentration-time data analysis The main pharmacokinetic parameters were as followsCmax=(429 00?108 80)ng/ml,Tmax=(0 91?0 40)h,AUC0~36(calculated by trapezoid method)=(3 312 72?682 39)ng/(h?ml)CONCLUSION:
The method was accurate,sensitive and reliable It is applicable to determine the concentration of cetirizine hydrocloride in human plasma;The main pharmaconetic parameters of the domestic cetirizine hydrocloride tablet were similar to those reported at home and abroad,so it could be extensively used in clinic
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2001
Type:
Article
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