Experiment Study on the Quality Standard and Formulation Screening of Bergenin Tablets / 中国药房
China Pharmacy
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-519325
ABSTRACT
OBJECTIVE:
To screen the optimum formulation of bergenin tablet and to establish an analysis method for measuring the content of bergenin in the tabletsMETHODS:
The L3(34) orthogonal table and the parameter of in vitro dissolubility(Td) was employed to select the optimum formulation by taking LS-HPC,tween-80-starch,and starch as the three main factors,and three levels were adopted for each-factor The dual-wavelength spectrophotography was employed to determine the content of bergenin in the tabletsRESULTS:
The experimental results indicated that LS-HPC and tween-80-starch were the chief factors of influencing dissolution of tablet(P0 05) The optimum formulation was composed of bergenin0 125g,Ls-HPC0 0 186g,tween 80-starch0 0 248g,starch0 1 354g,magnesium stearate0 0 032g The dual-wavelength spectrophotography was convenient and accurate The average recovery rate of bergenin was (100 92?0 87)%(n=8)CONCLUSION:
The formulation has merits of low price of supplementary materials,rapid release of effective component,simple manufacture technique,and stability in quality
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
/
Screening study
Language:
Chinese
Journal:
China Pharmacy
Year:
2001
Type:
Article
Similar
MEDLINE
...
LILACS
LIS