Study on Relationship between Lipid Perioxidation and the Level of Serum Estriol and Expression of the Estrogen Receptors on Placentae in Intrahepatic Cholestasis of Pregnancy / 中华围产医学杂志

ABSTRACT

Objective To explore the relationship between the changes of serum malondialdehyde(MDA),superoxidation dismutase (SOD) and the level of serum-estriol (E 3), ?-hCG, and expression of estrogen receptors(ER), HCG on placenta of intrahepatic cholestasis of pregnancy(ICP). Methods Thirty-three women with ICP and thirty normal pregnant women were enrolled in study. All elbow vein blood were drawn within half an hour before delivery. The level of SOD, MDA, E 3 and?-hCG were detected. Twenty cases of ICP group and control group were selected randomly and placental tissues were measured by using immunohistochemical method to assess the level of ER and hCG. Results The level of MDA and free E 3 in ICP group were [(6.4?2.1) mol/L],and were [(19?9 ng/ml)] higher than that in control group [(5.2?1.4 mol/L)], and [(14?6 ng/ml)] (P