Experimental Study of Anti-hepatofibrotic Action of 18?-glycyrrhizic Acid in Rats / 中国药房

ABSTRACT

OBJECTIVE:To study the anti-hepatofibrotic action of 18?-glycyrrhizic acid(18?-GL) and gamma interferon (IFN-?) in rats METHODS:The rat model of liver fibrosis was induced by dimethyl nitrosamine(DMN),18?-GL or IFN-? was administrated before and 5 weeks after giving DMN,to prevent and treat liver fibrosis The pathological changes and degree of fibrosis in the liver were observed and compared with that of DMN control group RESUTLSCompared to DMN control group,the collagen deposition in both 18?-GL and INF-? groups was significantly slight in degree(P