Study on the Preparation and in Vitro Dissolubility of Ofloxacin Hollow Suppository / 中国药房
China Pharmacy
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-519762
ABSTRACT
OBJECTIVE:
To prepare ofloxacin hollow suppository(OHS) and to observe its in vitro dissolubility.METHODS:
OHS was prepared with PEG 6000,PEG 400 and Carbopol-940 as wase material and wax as retardant.The content of ofloxacin in OHS was determined with the first order derivative UV-spectrophotometry.RESULTS:
The wax,as a retardant,could retard the release of drug.The in vitro dissolution of OHS revealed the first order dissolution patternK0~1=27.81/h,indicating a speedy effect,K2~6=5.94/h,indicating sustained-release effect.CONCLUSION:
This preparation is feasible in technology and controllabe in quality.The preparation of OHS extends the kinds of dose-form of ofloxacin
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2001
Type:
Article
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