Preparation and Pharmacokinetic Study of Gastroretentive Slow-released Tinidazole Capsules / 中国药房
China Pharmacy
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-519918
ABSTRACT
OBJECTIVE:
To prepare gastroretentive slow- released Tinidazole capsules so that the drug can stay at the stomach and act to infective lesions for a long period of time so as to improve the therapeutic efficacy and reduce the adverse reactions.METHODS:
The content of Tinidazole was determined by UV - spectrophotometry, the quality standard was established, the stability was studied, the levels of Tinidazole in saliva were detected with HPLC in human body and in vitro dissolubility and human bioavailability were studied .RESULTS:
The capsules were stable in quality.The retentive period in artificial gastric juice has reached lOh and in vitro dissolubility(0.5h - 5h) could be described as zero order dissolution .The bioavailability was 163.6% .CONCLUSION:
Gastroretentive slow - released Tinidazole capsule was an effective agent for treating HP - related diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2001
Type:
Article
Similar
MEDLINE
...
LILACS
LIS