Effects of riboflavin and ascorbic acid on apoptosis and proliferative inhibition of mouse thymocytes induced by deoxynivalenol in vivo / 中国病理生理杂志

ABSTRACT

AIM: To explore the effects of riboflavin and ascorbic acid on the apoptosis induced by deoxynivalenol(DON) in mouse thymocytes. METHODS: The effects of riboflavin and ascorbic acid on the apoptosis and proliferation inhibition of thymocytes induced by DON in KM mice were studied with animal experiment, DNA agarose gel electrophoresis and flow cytometric DNA content analysis. RESULTS: Apoptosis rate of thymocytes in DON (4 mg/kg) treated group was 13 73%?1 53% The percentages of apoptosis in riboflavin (1 25 mg/kg-10 mg/kg) and ascorbic acid (25 mg/kg-100 mg/kg) pretreated thymocytes groups were significantly lower than that in DON group ( P