Study on painless gastroscopy with propofol and midazolam / 中华消化内镜杂志

ABSTRACT

Objective To study the efficacy and safety of sedation for gastroscopy with a combined use of propofol and midazolam compared to a control, non-sedative group , with the goal of establishing a method of painless gastroscopy. Methods One thousand nine hundred fifteen patients in sedative group were given intravenous propofol and midazolam . Patients feeling and discomfort, operators satisfaction and operative duration were compared with the control group ( n = 640, without sedation ) . The changes of blood pressure, heart rate and blood oxygen saturation were recorded and analysed. Results One thousand nine hundred patients(99. 2% ) in sedative group and 224 patients(35. 0% ) in control group did not complain any discomfort and pain during gastroscopy(P