Clinical Study on Domestic Amifostine in Prevention of Nephrotoxicity of Cisplatinum / 中国药房
China Pharmacy
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-520053
ABSTRACT
OBJECTIVE:
To observe the efficacy and safety of amifostine in prevention of nephrotoxicity induced by cisplatinum(DDP)METHODS:
46 patients with malignant tumors were randomly divided into two groups23 in chemotherapy and amifostine group(trial group)and 23 in single chemotherapy group(control group) Laboratory exmination indices such as blood routine,blood calcium,liver function,blood urea nitrogen,cretinine,and urinary ?1-microglobulin(?1-MG),albumin(Alb) and transferrin(TRF) were monitored at different time period points before and after treatmentRESULTS:
20 patients in each group completed the whole trial In the two periods of therapy,the peak values of ?1-MG,Alb and TRF of trial group were lower than those of control group(P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2001
Type:
Article
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