Serum Level of Interferon-inducible T Cell Alpha Chemoattractant(I-TAC)in Patients With Systemic Lupus Erythematosus / 中华皮肤科杂志
Chinese Journal of Dermatology
; (12)1995.
Article
in Zh
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| ID: wpr-520172
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ABSTRACT
Objective To determine the relationship between serum interferon-inducible T cell alpha chemoattractant(I-TAC)levels and disease activity in patients with systemic lupus erythematosus(SLE).Methods Serum level of I-TAC was measured by sandwich ELISA.Results①Serum level of I-TAC was significantly increased in patients with SLE as compared with controls,and significantly higher in patients with active SLE than those of the inactive.Serum level of I-TAC showed significant positive correlation with disease activity,erythrocyte sedimetation rate(ESR),logarithm of serum ANA titer,and negative correlation with serum C3levels.②Serum level of I-TAC was significantly higher in patients with renal involvement than those without renal diseases.Conclusions These results suggest that I-TAC might be involved in the pathogenesis of SLE,and its serum level might be used as a good indicator for the disease activity of SLE and renal involvement.
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WPRIM
Language:
Zh
Journal:
Chinese Journal of Dermatology
Year:
1995
Type:
Article